Does my female dog/cat need to have one litter before we have her spayed?

No, in fact, females spayed BEFORE the first heat are 17 times less likely to develop breast cancer later in life. Breast cancer in dogs has a 50% malignancy rate, and it's 80% in cats! In addition, as much as we love puppies and kittens, there just aren't enough good homes for them all. We strongly recommend spaying females before 7 months of age, but it can be done at any time during a pet's life.

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